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KMID : 0895420070170020081
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Journal of Korean Society of Occupational and Enviromental Hygiene
2007 Volume.17 No. 2 p.81 ~ p.88
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The Level of urinary malondialdehyde concentrations in vinyl chloride monomer exposure workers
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Kim Hyun-Soo
Kim Chi-Nyon
Won Jong-Uk
Park Jun-Ho
Kim Gwang-Suk
Ahn Mi-Hyun
Roh Jae-Hoon
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Abstract
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The aim of this study was to investigate whether the exposure to vinyl chloride monomer(VCM) induces lipid peroxidation in workers by evaluating the concentration of malondialdehyde(MDA) in the urine in order to assess worker’s oxidative stress due to exposure of vinyl chloride monomer. The subjects investigated in the study were divided into the experimental group; 18 workers exposed to VCM, and the control group; 19 workers unexposed to VCM. A gas chromatography/pulsed flame photometric detector(GC/PFPD) was utilized to analyze thiodiglycolic acid(TDGA), which was methylated with trimethylsilyldiazomethane (2.0M in diethyl ether) in urine and the urinary MDA, the product of lipid peroxidation, was determined by highperformance liquid chromatography/ultraviolet-visible detector after derivatized with 2,4-dinitrophenylhydrazine(DNPH). The concentrations of urinary TDGA in controls and VCM exposure workers were 0.13(2.01)mg/g Cr. GM(GSD) and 0.35(1.96)mg/gCr. GM(GSD), respectively. The concentrations of urinary MDA were 0.12(2.21)μmol/gCr. GM(GSD) in controls and 1.35(1.79)μmol/gCr. GM(GSD) in VCM exposure workers.As a result of simple regressions analysis between urinary concentration of TDGA and MDA in VCM exposure workers,it was found that the R2 value was 0.261 (p=0.03) and the drinking and smoking did not affect their level. In conclusion, the workers exposed to VCM have a potentially to suffered by oxidative stress due to VCM exposure and the urinary MDA can be applicable to the marker of effect to assess the level of worker’s VCM exposure.
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KEYWORD
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vinyl chloride monomer, malondialdehyde, Lipid peroxidation
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